Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 23, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Advanced optimization methods for whole pelvic and local prostate external beam therapy.

Martin Buschmann¹, Yvette Seppenwoolde¹, Tilo Wiezorek²

¹Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna/AKH Wien, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)

|April 7, 2016

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ATR inhibition sensitizes pancreatic cancer cells to cytotoxic and immunogenic effects of X-ray and carbon ion irradiation.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026

Same author

PARP7 inhibitors enhance the immunogenic effects of radiation in pancreatic cancer cells.

Molecular therapy. Oncology·2026

Same author

Calculating biological dose distributions in hadrontherapy using GATE: the BioDose actor.

Physics in medicine and biology·2026

Same author

A probabilistic framework for risk-bounded patient-specific quality assurance in volumetric modulated arc therapy based on measured and calculated gamma pass rates.

Zeitschrift fur medizinische Physik·2026

Same author

A commemoration and appreciation of Professor Ben Mijnheer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026

Same author

Assessing the technical capability of a room- and a gantry-mounted kV imaging device for intra-fractional fluoroscopy during stereotactic lung radiotherapy at a C-arm linear accelerator.

Physics and imaging in radiation oncology·2026

Multicriteria optimization (MCO) for prostate VMAT planning offers comparable plan quality to standard methods with reduced planning time. While manual VMAT slightly improved organ-at-risk sparing in whole pelvic treatments, MCO demonstrated efficiency for prostate cancer radiotherapy.

Area of Science:

Radiation Oncology
Medical Physics
Cancer Treatment Planning

Background:

Radiation treatment planning involves balancing multiple, often conflicting, objectives.
Multicriteria optimization (MCO) is a promising approach for addressing these complex planning challenges.

Purpose of the Study:

To investigate a multicriteria optimization (MCO) algorithm for volumetric modulated arc therapy (VMAT) planning in prostate cancer.
To compare the VMAT-MCO technique against standard inverse VMAT (sVMAT) and Tomotherapy planning.

Main Methods:

A two-stage VMAT plan was generated for ten prostate cancer patients.
Stage 1 delivered 22Gy to the prostate; Stage 2 delivered 50.4Gy to lymph nodes and 56Gy to the prostate with a simultaneous integrated boost.
Plans were compared for quality and planning time efficiency across VMAT-MCO, sVMAT, and Tomotherapy.

Keywords:

Multicriteria optimization Tomotherapy VMAT Whole-pelvic prostate radiotherapy

More Related Videos

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Related Experiment Videos

Last Updated: Mar 23, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Main Results:

Plan quality was similar across all techniques.
sVMAT showed superior rectum and bowel sparing compared to VMAT-MCO in whole pelvic treatments.
Tomotherapy resulted in higher bladder dose in stage 1 and lower rectal dose in stage 2 compared to VMAT-MCO.
MCO reduced planning time by up to 12 minutes for stage 1 and 38 minutes for stage 2 plans.

Conclusions:

MCO effectively generates conformal prostate VMAT plans with minimal workload for prostate-only and prostate plus lymph node treatments.
Manual VMAT optimization provided slightly better organ-at-risk sparing in whole pelvic plans compared to VMAT-MCO.
For primary prostate treatment, VMAT-MCO achieved equal plan quality to manual optimization.