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Updated: Mar 23, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
12.5K
Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept
T G Shrihari1, V Vasudevan1, V Manjunath1
1Department of Oral Medicine and Radiology, Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka, India.
The Gulf Journal of Oncology
|April 7, 2016
Summary
Chronic periodontitis, driven by oral bacteria, promotes cancer development through sustained inflammation and immune suppression. Key mediators released during this process facilitate tumor growth and metastasis.
Area of Science:
- Oral microbiology and immunology
- Cancer biology and immunology
Background:
- Periodontal disease involves bacterial infection, leading to chronic inflammation, bacteremia, and immune responses.
- Long-term exposure to oral bacteria and toxins triggers immune evasion, releasing growth factors, free radicals, cytokines, and matrix metalloproteinases.
Purpose of the Study:
- To analyze the role of chronic inflammatory mediators in chronic periodontitis.
- To investigate the progression of periodontitis-associated inflammation to cancer.
Main Methods:
- Review of evidence on inflammatory mediators in periodontitis.
- Analysis of immune evasion mechanisms and their downstream effects.
- Examination of immature myeloid cell involvement in inflammation and tumor progression.
Main Results:
- Chronic inflammation releases factors like FGF, EGF, TGF-Beta, ROS, NOS, TNF-alpha, IL-1 Beta, IL-6, and MMP-9.
- Immature myeloid cells contribute to immunosuppression and tumor progression.
- Mediators activate transcription factors (NF-KB, STAT3) promoting cancer hallmarks.
Conclusions:
- Chronic periodontitis mediators play a significant role in cancer progression.
- Inflammatory pathways in periodontitis can drive genetic instability, proliferation, and metastasis.
- Understanding these links is crucial for cancer prevention and treatment strategies.
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