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Updated: Mar 23, 2026

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates
Published on: September 26, 2013
Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances
David Warwick1, José M Arandes-Renú2, Giorgio Pajardi3
1a The Hand Clinic, University Hospital Southampton , Hampshire , UK ;
Objective:
This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH).
Methods:
This review is based on a literature review and practical experience.
Results:
This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies.
Conclusion:
CCH has an evolving role as one of the tools available for treating Dupuytren's disease.
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