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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Recent developments in receptor tyrosine kinases targeted anticancer therapy.
Samir H Raval1, Ratn D Singh2, Dilip V Joshi1
1Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Banaskantha - 385 506, Gujarat, India.
Receptor tyrosine kinases (RTKs) are crucial for cell signaling and cancer development. This review covers small molecules and antibodies targeting RTKs for novel anticancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Receptor tyrosine kinases (RTKs) play vital roles in cellular signaling.
- Aberrant RTK activity (overexpression, mutations) drives cancer development.
- RTKs are key targets for anticancer drug development.
Purpose of the Study:
- To review small molecule drugs and monoclonal antibodies targeting RTKs.
- To discuss RTK subfamilies investigated for cancer therapy.
- To highlight approved and investigational anti-RTK therapies.
Main Methods:
- Literature review of RTK-targeted anticancer agents.
- Focus on specific RTK subfamilies: EGFR, VEGFR, FGFR, IGFR, HGFR.
- Analysis of approved and investigational drugs and antibodies.
Main Results:
- Several RTK subfamilies are actively targeted in cancer therapy.
- Small molecules and monoclonal antibodies show promise.
- A range of therapies are approved or in clinical investigation.
Conclusions:
- RTK-targeted therapies represent a significant advancement in oncology.
- Continued research into RTK inhibitors and antibodies is crucial.
- Personalized medicine approaches may enhance RTK-targeted treatment efficacy.
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