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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
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Hepatitis E virus as an emerging zoonotic pathogen
Woo-Jung Park1, Byung-Joo Park1, Hee-Seop Ahn1
1Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
Journal of Veterinary Science
|April 7, 2016
Summary
Hepatitis E is a global public health issue, particularly in developing nations. This review covers hepatitis E virus (HEV) characteristics, zoonotic transmission, and vaccine development.
Area of Science:
- Public Health
- Virology
- Zoonotic Diseases
Background:
- Hepatitis E outbreaks pose significant public health risks globally, especially in developing countries.
- The hepatitis E virus (HEV) causes acute infections, with high mortality rates in pregnant women.
- HEV genotypes 3 and 4 are zoonotic, found in both humans and animals like pigs.
Purpose of the Study:
- To review the general characteristics of hepatitis E.
- To summarize HEV infection status in animals and humans.
- To discuss zoonotic transmission routes and vaccine development for HEV.
Main Methods:
- Literature review of existing studies on Hepatitis E.
- Analysis of HEV genotypes, seroprevalence, and transmission modes.
- Assessment of HEV vaccine development progress.
Main Results:
- HEV is a widespread zoonotic pathogen transmitted through contaminated food and water.
- Undercooked animal meats are a primary source of HEV infection in developed countries.
- Transfusion- and transplantation-related HEV infections are emerging concerns.
Conclusions:
- Hepatitis E represents a significant global health challenge requiring multifaceted control strategies.
- Understanding zoonotic transmission is crucial for preventing HEV infections.
- Ongoing research into HEV vaccines is vital for future disease management.
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