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Changes in Lipid Profiles of HIV(+) Adults over Nine Months at a Harare HIV Clinic: A Longitudinal Study

Danai Tavonga Zhou1, Doreen Nehumba2, Olav Oktedalen3

  • 1Institute of Clinical Medicine, University in Oslo, Oslo University Hospital, P.O. Box 1171, Blindern, 0318 Oslo, Norway; Department of Medical Laboratory Sciences, College of Health Sciences, University of Zimbabwe, P.O. Box AV 178, Avondale, Harare, Zimbabwe.

Biochemistry Research International
|April 7, 2016
PubMed

Insights

HIV infection and antiretroviral therapy (ART) can alter lipid profiles. This study found reduced cardiovascular risk in HIV patients over nine months, mainly due to increased HDL cholesterol.

Area of Science:

  • Biochemistry
  • Metabolic Medicine
  • Cardiovascular Health

Background:

  • HIV infection and antiretroviral therapy (ART) are known to influence biochemical and metabolic parameters, including lipid profiles.
  • Dyslipidemia is common in individuals with HIV, impacting their cardiovascular health.
  • Understanding lipid profile changes is crucial for managing long-term health outcomes in HIV patients.

Purpose of the Study:

  • To compare changes in lipid profiles among HIV-positive outpatients over a nine-month period.
  • To assess the impact of HIV infection and ART on lipid parameters and cardiovascular risk.
  • To investigate trends in total cholesterol (TC), HDL cholesterol, and TC/HDL ratio.

Main Methods:

  • A nine-month observational study involving 171 HIV-positive outpatients.
  • Patients were categorized as ART-naïve or ART-experienced, with classification based on intent-to-treat.
  • Lipid profiles (TC, HDL) were measured at baseline and follow-up.

Main Results:

  • Over 60% of patients exhibited dyslipidemia at baseline or follow-up, though mean lipid values remained within normal limits.
  • ART-experienced patients had slightly higher mean TC and HDL levels at baseline and follow-up.
  • A notable increase in HDL was observed in ART-naïve patients compared to ART-positive patients, leading to a decreased TC/HDL ratio in both groups.

Conclusions:

  • HIV-positive patients frequently experience dyslipidemia, but average atherogenic lipid levels did not significantly change over nine months.
  • The observed increase in HDL cholesterol suggests a potential reduction in cardiovascular disease (CHD) risk.
  • Long-term monitoring of lipid profiles is essential for managing cardiovascular health in the context of HIV infection and ART.

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