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Updated: Mar 23, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
[Maturity onset diabetes of the young (MODY) - screening, diagnostic and therapy]
Susanne Kaser1,2, Michael Resl3
1Department für Innere Medizin 1, Medizinische Universität Innsbruck, Innsbruck, Österreich. Susanne.Kaser@i-med.ac.at.
Abstract:
Maturity onset diabetes of the young (MODY) is a group of monogenetic diabetes types affecting up to 2% all known diabetics. Transcription factor MODY (HNF1α, HNF4α), the most frequent forms of MODY, allow treatment with sulfonylureas, mutations of glucokinase (GCK-MODY) usually do not require any therapy. Especially in younger patients correct diagnosis of MODY often results in discontinuation of insulin therapy and initiation of a sulfonylurea. Accordingly, in patients with diabetes onset below age of 25 years, with a positive family history for diabetes and negative autoantibodies screening for MODY is recommended.
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