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Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Isolation of Campylobacter fetus from recent cases of human vibriosis

A F Hallett, P L Botha, A Logan

    The Journal of Hygiene
    |December 1, 1977
    PubMed

    Insights

    Campylobacter fetus, a cause of human vibriosis, was identified in five patients, including children with malnutrition. Despite treatment, three patients died, suggesting potential endogenous sources of infection.

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Clinical Bacteriology

    Background:

    • Campylobacter fetus is an opportunistic pathogen.
    • Human infections with Campylobacter fetus are rare but can be severe.

    Purpose of the Study:

    • To report on five cases of human vibriosis caused by Campylobacter fetus.
    • To investigate the clinical presentations and outcomes of these infections.
    • To discuss the potential sources and epidemiology of Campylobacter fetus infections.

    Main Methods:

    • Bacterial isolation and identification from blood cultures.
    • Subtyping of Campylobacter fetus isolates (subsp. intestinalis and subsp. jejuni).
    • Serological comparison of isolates with known strains.

    Main Results:

    • Campylobacter fetus was isolated from five patients (two adults, three children).
    • Clinical presentations included pericarditis, recurrent pyrexia, and diarrhea.
    • Campylobacter fetus subsp. intestinalis resembled cattle strains; subsp. jejuni was found in children with kwashiorkor or neonatal sepsis.
    • Three patients died despite antibiotic treatment.

    Conclusions:

    • Campylobacter fetus can cause severe vibriosis in diverse patient groups.
    • Infection may originate from the patient's endogenous flora.
    • Prompt diagnosis and appropriate therapy are crucial, though outcomes can be poor.

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