Neolignans from Selaginella moellendorffii
Jing-Xian Zhuo1, Yue-Hu Wang2, Xing-Li Su3
1Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
Natural Products and Bioprospecting
|April 8, 2016
Summary
Two new neolignans were isolated from Selaginella moellendorffii. Several compounds demonstrated significant activity in inhibiting adenosine diphosphate (ADP) or collagen-induced platelet aggregation.
Area of Science:
- Phytochemistry
- Pharmacology
Background:
- Selaginella moellendorffii is a plant species known for its diverse chemical constituents.
- Neolignans are a class of natural products with various biological activities.
Purpose of the Study:
- To isolate and characterize new compounds from Selaginella moellendorffii.
- To evaluate the anti-platelet aggregation activity of isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation through spectroscopic data analysis (e.g., NMR, MS).
- In vitro assays to measure inhibition of platelet aggregation induced by ADP or collagen.
Main Results:
- Two new neolignans, selaginellol (1) and selaginellol 4'-O-β-D-glucopyranoside (2), were identified.
- Compounds 8, 11, 12 (neolignans), 14 (flavanone), and 16 (alkaloid) exhibited inhibitory effects on platelet aggregation.
- Dihydrobenzofuran neolignans (8, 11, 12) showed greater potency than other neolignan types.
- Glucosidation enhanced the activity of dihydrobenzofuran neolignans.
Conclusions:
- Selaginella moellendorffii is a valuable source of bioactive neolignans.
- Specific neolignans from this species possess potent anti-platelet aggregation properties.
- Structural modifications, such as glucosidation, can modulate bioactivity.
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