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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

205
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

123
Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

305
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Related Experiment Video

Updated: Mar 23, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
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Liposomes as Advanced Delivery Systems for Nutraceuticals.

Christopher W Shade1

  • 1, is president of Quicksilver Scientific, LLC, in Lafayette, Colorado.

Integrative Medicine (Encinitas, Calif.)
|April 8, 2016
PubMed
Summary

Liposomes, versatile delivery vehicles, enhance nutrient absorption orally by protecting against stomach acid. Their use in the nutritional industry is rapidly expanding, offering advanced delivery options.

Area of Science:

  • Nanotechnology
  • Biopharmaceutics
  • Nutraceuticals

Background:

  • Liposomes, investigated since the 1970s, are biocompatible delivery systems for hydrophilic and hydrophobic agents.
  • Commercial success of liposome technology was achieved in the late 1990s, enabling wider applications.
  • Advancements in phospholipid quality and homogenization equipment have spurred recent oral delivery innovations.

Purpose of the Study:

  • To highlight the evolving role of liposomes in drug and nutrient delivery.
  • To discuss the recent emergence and future growth of oral liposome applications.
  • To emphasize the potential of advanced liposome formulations in the nutritional industry.

Main Methods:

  • Review of liposome technology development and applications.

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  • Analysis of factors enabling recent advances in oral liposome delivery.
  • Projection of future trends in liposome-based nutritional products.

    • Main Results:

    • Liposomes facilitate effective oral absorption and protect substances from stomach acid degradation.
    • The nutritional industry is experiencing rapid growth in liposome utilization.
    • High-quality liposome formulations offer improved delivery of complex compounds and botanicals.

    Conclusions:

    • Liposome technology has matured, enabling successful commercial products and innovative delivery systems.
    • Oral liposome delivery is a rapidly growing field, driven by technological advancements.
    • The nutritional sector will increasingly adopt liposomes for advanced, less-invasive active ingredient delivery.