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Human longevity: Genetics or Lifestyle? It takes two to tango
Giuseppe Passarino1, Francesco De Rango1, Alberto Montesanto1
1Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy.
Immunity & Ageing : I & A
|April 8, 2016
Summary
Genetic and lifestyle factors significantly influence human longevity and healthy aging. Understanding the interplay between genetics, epigenetics, and environment is key to promoting a longer, healthier lifespan.
Area of Science:
- Genetics and Epigenetics
- Aging Research
- Longevity Studies
Background:
- Human longevity is influenced by a complex interplay of genetic and non-genetic factors.
- Approximately 25% of human longevity variation is attributed to genetic factors.
- Genes involved in cellular maintenance and metabolism are crucial for aging phenotypes.
Purpose of the Study:
- To explore the genetic and molecular underpinnings of aging and longevity.
- To investigate the role of nutrient-sensing pathways and calorie restriction in lifespan modulation.
- To understand the impact of epigenetic modifications on aging quality and rate.
Main Methods:
- Analysis of family studies to determine the heritability of longevity.
- Investigation of genes related to cellular metabolism and nutrient-sensing signaling pathways.
- Examination of epigenetic modifications as biomarkers and modulators of aging.
Main Results:
- Genetic factors significantly impact cellular maintenance and metabolism, influencing aging.
- Calorie restriction and efficient nutrient metabolism can modulate lifespan by enhancing cellular upkeep.
- Epigenetic modifications are sensitive to aging and influenced by genetics and lifestyle, serving as aging biomarkers.
Conclusions:
- Interventions targeting the interaction between genetic predisposition and environmental factors are crucial for achieving longevity.
- A holistic approach considering genetics, epigenetics, diet, and lifestyle is essential for healthy aging.
- Understanding these complex interactions can guide strategies to promote longer and healthier lives.
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