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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Mar 23, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Novel Therapies in Development for Metastatic Colorectal Cancer.

Michael S Lee1, Scott Kopetz2

  • 1Division of Cancer Medicine.

Gastrointestinal Cancer Research : GCR
|April 8, 2016
PubMed
Summary

Metastatic colorectal cancer (CRC) remains a significant cause of cancer death. This review highlights novel therapies and biomarkers under investigation to improve treatment outcomes for patients with advanced CRC.

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Area of Science:

  • Oncology
  • Medical Research

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality in the United States.
  • Despite therapeutic advances, metastatic CRC continues to have a poor prognosis, necessitating novel treatment strategies.

Purpose of the Study:

  • To review promising novel therapeutic agents currently under investigation for metastatic colorectal cancer.
  • To discuss the role of biomarkers in patient selection for clinical trials in metastatic CRC.

Main Methods:

  • Literature review of preclinical and clinical studies on novel agents for metastatic CRC.
  • Analysis of emerging research in cancer biology, including growth factor signaling, angiogenesis, and cancer immunology.
  • Examination of biomarker-driven patient stratification in clinical trials.

Main Results:

  • Several novel therapeutic agents targeting key cancer pathways show promise in early-stage investigations.
  • Biomarker-guided patient selection is becoming increasingly important for rational drug development in CRC.
  • Advances in understanding cancer immunology and signaling pathways are paving the way for targeted therapies.

Conclusions:

  • Novel therapeutic agents and biomarker-driven approaches offer hope for improved outcomes in metastatic CRC.
  • Continued research into cancer biology is crucial for developing more effective treatments for advanced colorectal cancer.
  • Personalized medicine strategies are essential for advancing the care of patients with metastatic CRC.