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Updated: Jul 31, 2026

Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
A multivariate approach to analyzing the relation between occlusion and craniofacial morphology
S D Keeling1, M L Riolo, R E Martin
1Department of Orthodontics, University of Florida, Gainesville.
Combinations of occlusal features showed a moderate association with craniofacial skeletal morphology in children. However, a general link between malocclusion severity and skeletal type was not found.
Area of Science:
- Orthodontics and Dentofacial Orthopedics
- Craniofacial Biology
- Dental Morphology
Background:
- Understanding the relationship between dental occlusion and underlying skeletal structure is crucial for diagnosing and treating malocclusion.
- Previous research has explored these associations, but comprehensive analyses integrating multiple occlusal and skeletal variables are ongoing.
Purpose of the Study:
- To investigate the associations between various occlusal characteristics and craniofacial skeletal morphology in children with early permanent dentition.
- To determine if a malocclusion severity index correlates with specific craniofacial skeletal patterns.
Main Methods:
- Utilized univariate and multivariate statistical methods, including linear correlation, stepwise multiple regression, and canonical correlation analyses.
- Assessed multiple occlusal features (molar relation, overjet, overbite, anterior crowding) and angular skeletal measures from study casts and lateral cephalometric radiographs of 164 children.
- Examined the correlation between the Occlusal Index (a malocclusion severity index) and skeletal morphology.
Main Results:
- Individually and in combination, occlusal features demonstrated weak associations with individual skeletal measures (r² ≤ 0.35).
- A significant association was found between combined occlusal features and combined skeletal measures (R² = 0.66, p = 0.0001).
- The Occlusal Index did not effectively identify specific craniofacial morphologies.
Conclusions:
- Specific combinations of occlusal characteristics may be linked to particular craniofacial skeletal types.
- A generalized association between malocclusion severity and craniofacial morphology could not be established from this study.
- Further research is needed to elucidate the complex interplay between occlusion and skeletal development.
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