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Supporting data for the effect of gamma-secretase inhibitors in osteoclast differentiation and spreading

Won Jong Jin1, Bongjun Kim1, Jung-Wook Kim1

  • 1Department of Cell and Developmental Biology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea.

Data in Brief
|April 8, 2016
PubMed

Insights

Gamma-secretase inhibitors (GSIs) effectively block Notch signaling, inhibiting osteoclast differentiation and spreading. This research provides insights into optimal GSI treatment doses for potential therapeutic applications.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Pharmacology

Background:

  • Notch2 signaling is implicated in osteoclast resorption.
  • Osteoclast differentiation and function are critical in bone remodeling.

Purpose of the Study:

  • To evaluate the inhibitory potential of gamma-secretase inhibitors (GSIs) on osteoclastogenesis.
  • To assess the effect of GSIs on osteoclast differentiation and spreading using mouse bone marrow-derived macrophages (BMMs).

Main Methods:

  • Utilized gamma-secretase inhibitors (GSIs) to block Notch signaling.
  • Employed mouse bone marrow-derived macrophages (BMMs) to study osteoclastogenesis.
  • Measured the impact of GSIs on osteoclast differentiation and cell spreading.

Main Results:

  • GSIs demonstrated significant inhibitory effects on osteoclastogenesis.
  • GSIs affected the normal spreading and differentiation of osteoclasts.
  • The study provides data relevant to in vivo physiological conditions.

Conclusions:

  • GSIs represent a valuable approach for modulating osteoclast activity.
  • This data can inform the selection of GSI treatment doses.
  • Understanding GSI effects on osteoclasts offers potential therapeutic insights.
Keywords:
DifferentiationGSINotchOsteoclastSpreading

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