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Related Experiment Video

Updated: Mar 23, 2026

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

Kill: boosting HIV-specific immune responses.

Lydie Trautmann¹

¹aUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.

Current Opinion in HIV and AIDS

|April 8, 2016

Summary

This summary is machine-generated.

Boosting HIV-specific CD8 T cells is key to purging latent HIV reservoirs. New immune strategies aim to enhance these cells for a potential HIV cure without antiretroviral treatment.

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Last Updated: Mar 23, 2026

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

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Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

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In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

Published on: October 15, 2013

Area of Science:

Immunology
Virology
HIV Research

Background:

The latent HIV reservoir persists despite viral suppression.
A 'Shock and Kill' strategy requires reactivating latent HIV and eliminating infected cells.

Purpose of the Study:

To explore immune interventions for boosting HIV-specific CD8 T cells.
To enhance the elimination of HIV-infected cells and achieve viral control.

Main Methods:

Evaluating immune interventions like early suppression, adoptive cell transfer, therapeutic vaccination, and immunomodulatory molecules.
Developing new assays to measure CD8 T cell killing and antiviral function.
Utilizing in-vivo and in-silico models to test combined HIV reactivation and immune therapies.

Main Results:

Recent studies provide rationale for immune interventions targeting HIV-specific CD8 T cells.
New assays enable better assessment of immune-based therapy efficacy.
Combined strategies can be tested in preclinical models to accelerate clinical trials.

Conclusions:

New immunobased strategies are being developed to enhance HIV-specific CD8 T cells.
The goal is to purge HIV-infected cells and achieve spontaneous viral control.
This research aims for a functional HIV cure without ongoing antiretroviral therapy.