Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

53.4K
Overview
53.4K
Vaccines01:21

Vaccines

25
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
25

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redefining Drug Immune Recognition: A Radically Reconfigured Molecular Architecture Enables Broad Fentanyl-Class Protection.

Journal of medicinal chemistry·2026
Same author

Fentanyl-Rewired: A 2‑Azaspiro[3.3]heptane Core Preserves μ‑Opioid Function.

ACS medicinal chemistry letters·2026
Same author

Bifunctional Behavior of Conformationally Constrained Methamphetamine Analogs: Unexpected Heteroclitic Immune Response and Antagonist Effects Altering Methamphetamine and Fentanyl Pharmacology.

Journal of medicinal chemistry·2025
Same author

Solid-phase synthesis of a pyrrole library and identification of bioactive compounds.

Bioorganic & medicinal chemistry letters·2025
Same author

Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site.

Journal of medicinal chemistry·2025
Same author

Investigations of Thiosemicarbazides as Botulinum Toxin Active-Site Inhibitors: Enzyme, Cellular, and Rodent Intoxication Studies.

ACS infectious diseases·2024

Related Experiment Video

Updated: Mar 23, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

8.1K

Methamphetamine Vaccines: Improvement through Hapten Design.

Karen C Collins1, Joel E Schlosburg1, Paul T Bremer1

  • 1Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM) and ‡Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of Medicinal Chemistry
|April 8, 2016
PubMed
Summary
This summary is machine-generated.

Developing a methamphetamine (MA) vaccine shows promise for addiction treatment. This study optimized vaccine design in mice, achieving a strong immune response that reduced MA-induced hyperactivity, offering a new avenue for combating MA addiction.

More Related Videos

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

10.8K
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.7K

Related Experiment Videos

Last Updated: Mar 23, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

8.1K
Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

10.8K
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.7K

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Methamphetamine (MA) addiction is a critical global health issue.
  • Existing treatments for MA addiction and relapse prevention are largely ineffective.
  • Novel therapeutic strategies are urgently needed to address the MA epidemic.

Purpose of the Study:

  • To develop and optimize a vaccine targeting methamphetamine (MA).
  • To evaluate the immunogenicity and efficacy of the MA vaccine in a preclinical model.
  • To explore a potential complementary strategy to current behavioral therapies for MA addiction.

Main Methods:

  • Optimization of hapten design and vaccine formulation for MA.
  • Administration of the developed vaccine in a mouse model.
  • Assessment of the elicited anti-MA immune response.
  • Measurement of methamphetamine-induced locomotor activity in vaccinated mice.

Main Results:

  • The optimized vaccine formulation successfully elicited a robust immune response against MA in mice.
  • Vaccination significantly reduced methamphetamine-induced locomotor activity.
  • The study demonstrates proof-of-concept for an anti-MA vaccine.

Conclusions:

  • Vaccine development targeting MA is a feasible strategy for addiction treatment.
  • The optimized MA vaccine shows potential in preclinical studies to mitigate drug-induced effects.
  • Further research is warranted to advance this vaccine approach for human clinical trials.