Left ventricular outflow tract obstruction in ICU patients
Michel Slama1, Christophe Tribouilloy, Julien Maizel
1aMedical Intensive Care Unit bDepartment of Cardiology, Amiens University Hospital cUnité INSERM 1088, Université Picardie Jules Verne, Amiens, France.
Current Opinion in Critical Care
|April 8, 2016
Summary
Left ventricular outflow tract obstruction (LVOTO) is common in ICU patients with septic shock. Treatment involves fluid resuscitation and beta-blockers, while discontinuing dobutamine infusion can resolve LVOTO.
Area of Science:
- Cardiology
- Intensive Care Medicine
- Hemodynamics
Background:
- Left ventricular outflow tract obstruction (LVOTO) is typically associated with hypertrophic cardiomyopathy.
- Traditionally defined by LV wall thickness ≥15 mm and peak Doppler gradient ≥30 mmHg.
- Recent findings indicate LVOT can occur in sepsis due to hypovolemia or hyperkinesis, leading to hemodynamic compromise.
Purpose of the Study:
- To review the occurrence and management of LVOTO in intensive care unit (ICU) patients, particularly those with septic shock.
- To highlight the evolving understanding of LVOT causes beyond hypertrophic cardiomyopathy.
Main Methods:
- Review of current literature on LVOTO in ICU settings.
- Analysis of factors contributing to LVOTO, including hypovolemia, septic shock, and pharmacologic interventions.
Main Results:
- LVOTO is frequently observed in ICU patients, especially during early septic shock.
- Causes include decreased preload (hypovolemia) and afterload (septic shock), increased heart rate, and LV hyperkinesis (e.g., dobutamine).
- Systolic anterior motion of the mitral valve is a common mechanism.
Conclusions:
- Prompt recognition and management of LVOTO in septic shock are crucial.
- Treatment strategies include fluid resuscitation, discontinuation of inotropic agents like dobutamine, and consideration of beta-blockers.
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