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Red cell fragmentation produced by renal artery stenosis
1Department of Medicine, Veterans Administration Medical Center, Nashville, TN 37212.
The American Journal of the Medical Sciences
|April 1, 1989
Summary
Renal artery stenosis can cause hemolytic anemia due to red blood cell trauma. Surgical correction of this arterial condition resolved the anemia in a reported case.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Nephrology
Background:
- Mechanical trauma to red blood cells can cause fragmentation hemolytic anemia.
- This condition is typically linked to cardiac or aortic abnormalities, or small artery diseases.
- Major aortic branch diseases, like renal artery stenosis, have not been previously associated with this syndrome.
Observation:
- A patient presented with severe, bilateral renal artery stenosis.
- The patient also exhibited fragmentation hemolytic anemia.
Findings:
- The patient's fragmentation hemolytic anemia resolved after surgical correction of the renal artery stenosis.
- This case demonstrates a novel association between renal artery stenosis and hemolytic anemia.
Implications:
- Renal artery stenosis should be considered in the differential diagnosis of unexplained fragmentation hemolytic anemia.
- Surgical intervention for renal artery stenosis may resolve associated hemolytic anemia.
- This finding expands the understanding of the pathophysiology linking vascular abnormalities to hematologic disorders.