Related Experiment Video
Updated: Mar 23, 2026

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
Voriconazole-Loaded Nanostructured Lipid Carriers for Ocular Drug Delivery
Lígia M Andrade1, Kamilla A D Rocha, Fernando A P De Sá
1*Laboratory of Pharmaceutical Technology, School of Pharmacy-Universidade Federal de Goiás (UFG), Goiânia, GO, Brasil; and †Laboratory of Food, Drugs and Cosmetics (LTMAC), Universidade de Brasília (UnB), Brasília, DF, Brasil.
Purpose:
To design and evaluate the potential of a topical delivery system for ocular administration of voriconazole, based on cationic nanostructured lipid carriers (NLCs).
Methods:
NLC dispersions composed of glyceryl behenate/capric caprylic triglyceride, polysorbate 80, sorbitan trioleate, and cetylpyridinium chloride were obtained and characterized. Ex vivo permeations experiments were performed to evaluate their drug delivery potential.
Results:
NLCs presented a mean diameter of 250.2 ± 03.1 nm, narrow polydispersity index (0.288 ± 0.03), positive zeta potential (31.22 ± 3.8 mV), and over 75% encapsulation efficiency. Ex vivo ocular experiments proved that NLCs were able to deliver therapeutically relevant drug amounts to the cornea after only 30 minutes (13.88 ± 0.24 μg/cm).
Conclusions:
The formulation was nonexpensive, easy to prepare, and composed of well-tolerated and accepted excipients. Further in vivo experiments are necessary to confirm the improved performance and tolerability of the formulation.
Related Concept Videos
Ophthalmic Drug Delivery Systems
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Site-Targeted
Modified-Release Drug Delivery Systems: Overview
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Oral Drug Delivery Systems: Introduction

