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Combinatorial Dansyl Library and its Applications to pH-Responsive Probes
Seong Cheol Hong, Dhiraj P Murale, Jun-Seok Lee1
1Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), P.O. Box: 136-791, Seoul, Republic of Korea. junseoklee@kist.re.kr.
Abstract:
Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.
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