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Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures
Carolyn J Steber1, Scott L Perkins2, Kira B Harris1
1Levine College of Health Sciences, Wingate University, Wingate, NC, USA.
The American Journal of Case Reports
|April 9, 2016
Summary
Metformin can cause fixed-drug eruptions (FDEs), a type of skin reaction. This case report highlights the importance of recognizing FDEs associated with this common diabetes medication.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Fixed-drug eruptions (FDEs) are characterized by recurrent cutaneous lesions upon re-exposure to a specific drug.
- While several drugs are commonly implicated, any medication can potentially trigger an FDE.
- Metformin, a widely prescribed antidiabetic drug, has limited documented association with FDEs.
Observation:
- A 56-year-old woman presented with recurrent, round, erythematous lesions on her palms and soles.
- These lesions consistently appeared after metformin exposure and resolved upon drug discontinuation.
- The Naranjo scale indicated a definite association between metformin and FDE in this patient.
Findings:
- This case report adds to the scarce literature on metformin-induced fixed-drug eruptions.
- The patient experienced characteristic FDE lesions attributed to metformin use.
Implications:
- Clinicians should consider metformin as a potential cause of FDEs in patients presenting with suggestive skin lesions.
- Increased awareness of metformin-associated FDEs is crucial for accurate diagnosis and management.
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