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Related Experiment Video

Updated: Mar 22, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
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Draft Genome Sequence of a Vancomycin-Resistant and Vancomycin-Dependent Enterococcus faecium Isolate.

Marion Blaschitz1, Sarah Lepuschitz1, Laura Wagner1

  • 1Institute of Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, Vienna, Austria.

Genome Announcements
|April 9, 2016
PubMed
Summary
This summary is machine-generated.

Vancomycin-resistant enterococci can become dependent on the antibiotic vancomycin. This study reports the genome of a vancomycin-dependent Enterococcus faecium strain that also shows partial teicoplanin dependence.

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Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Vancomycin-resistant enterococci (VRE) are significant healthcare-associated pathogens.
  • Antimicrobial use can lead to VRE colonization and potentially altered resistance mechanisms.
  • Prolonged vancomycin exposure may induce vancomycin dependence in VRE.

Purpose of the Study:

  • To characterize the genomic features of a vancomycin-dependent Enterococcus faecium isolate.
  • To investigate the genetic basis for vancomycin dependence and partial teicoplanin dependence.

Main Methods:

  • Whole-genome sequencing of the vancomycin-dependent Enterococcus faecium isolate.
  • Bioinformatic analysis of the draft genome sequence.

Main Results:

  • The draft genome sequence of the vancomycin-dependent Enterococcus faecium isolate was obtained.
  • The isolate exhibited partial dependence on teicoplanin in addition to vancomycin dependence.

Conclusions:

  • Vancomycin dependence is a potential evolutionary outcome in vancomycin-resistant enterococci.
  • The genomic data provides insights into the mechanisms underlying antibiotic dependence in Enterococcus faecium.
  • Further research is needed to understand the clinical implications of antibiotic-dependent VRE strains.