Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

821
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
821
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

735
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
735
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

909
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
909
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

970
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
970
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

7
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
7
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

441
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
441

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of innate immune cells with regulatory functions in subjects with a remote history of Kawasaki disease who lack natural regulatory T cell specificities.

Immunology letters·2026
Same author

Acute Intensification May Reduce Persistent Coronary Artery Damage from Kawasaki Disease in Infants Younger Than 6 Months.

The Journal of pediatrics·2026
Same author

Glucocorticoids in Kawasaki Disease - Refining Indications and the Science.

The New England journal of medicine·2026
Same author

Kawasaki Disease in Adults: A Call to Action to Manage Lifelong Coronary Risk.

Journal of the American College of Cardiology·2026
Same author

Minimal correlation but complementary diagnostic utility for plasma cell-free RNA and proteins.

Communications medicine·2026
Same author

Kawasaki Disease and the Importance of Family History.

JACC. Case reports·2026

Related Experiment Video

Updated: Mar 22, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.1K

Kawasaki Disease.

Jane W Newburger1, Masato Takahashi2, Jane C Burns3

  • 1Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

Journal of the American College of Cardiology
|April 9, 2016
PubMed
Summary
This summary is machine-generated.

Early treatment of Kawasaki disease with intravenous immunoglobulin significantly reduces coronary artery aneurysm risk. Untreated, this childhood vasculitis can lead to long-term heart complications, including myocardial infarction in young adults.

Keywords:
aneurysmcoronary aneurysmcoronary thrombosisimmunoglobulinintravenousmucocutaneous lymph node syndromemyocardial infarction

More Related Videos

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

844
Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

7.8K

Related Experiment Videos

Last Updated: Mar 22, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.1K
Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

844
Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

7.8K

Area of Science:

  • Pediatrics
  • Cardiology
  • Rheumatology

Background:

  • Kawasaki disease is a critical pediatric vasculitis impacting coronary arteries.
  • Delayed treatment elevates the risk of coronary artery aneurysms, a major cause of cardiac morbidity.
  • Aneurysms can progress, leading to stenosis and myocardial infarction, even in adulthood.

Purpose of the Study:

  • To highlight the critical importance of early intravenous immunoglobulin treatment for Kawasaki disease.
  • To underscore the long-term cardiovascular sequelae of untreated or delayed-treated Kawasaki disease.
  • To inform about the evolving nature of coronary artery aneurysms and their management.

Main Methods:

  • Review of clinical data and outcomes in Kawasaki disease patients.
  • Analysis of the impact of treatment timing on coronary artery aneurysm formation.
  • Longitudinal observation of aneurysm evolution and associated cardiovascular events.

Main Results:

  • Intravenous immunoglobulin within 10 days of fever onset reduces aneurysm risk fivefold.
  • Coronary artery aneurysms peak in size by 6 weeks but can progress over years.
  • Kawasaki disease is an emerging cause of acute coronary syndrome in young adults.

Conclusions:

  • Prompt diagnosis and treatment of Kawasaki disease are vital to prevent severe coronary artery damage.
  • Long-term cardiovascular surveillance is necessary for patients with Kawasaki disease, especially those with aneurysms.
  • Management strategies for Kawasaki disease-induced coronary artery disease include surgical and interventional approaches.