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Related Concept Videos

Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

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To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
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Related Experiment Video

Updated: Mar 22, 2026

Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow
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Hydroxyurea for abnormal TCDs: safe to switch?

Patrick T McGann1

  • 1CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER.

Blood
|April 9, 2016
PubMed
Summary
This summary is machine-generated.

For children with sickle cell anemia (SCA) and abnormal TCD velocities, hydroxyurea therapy or bone marrow transplant may replace chronic transfusions. This suggests a potential safe transition for some patients from transfusions to hydroxyurea.

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Area of Science:

  • Hematology
  • Pediatric Medicine
  • Neurology

Background:

  • Sickle cell anemia (SCA) is a genetic blood disorder.
  • Abnormal transcranial Doppler (TCD) velocities in SCA indicate a high risk of stroke.
  • Chronic red blood cell transfusions are a common treatment to prevent stroke in these patients.

Purpose of the Study:

  • To evaluate alternative treatments to chronic transfusions for pediatric SCA patients with abnormal TCD.
  • To assess the safety and efficacy of hydroxyurea therapy and bone marrow transplantation as replacements for transfusions.

Main Methods:

  • Retrospective analysis of a cohort of children with SCA and abnormal TCD velocities.
  • Comparison of outcomes between patients receiving chronic transfusions, hydroxyurea therapy, or bone marrow transplantation.

Main Results:

  • Hydroxyurea therapy or bone marrow transplantation can be safely used as alternatives to chronic transfusions.
  • These findings align with results from the TWiTCH study, supporting the transition of some patients to hydroxyurea.

Conclusions:

  • Hydroxyurea therapy and bone marrow transplantation represent viable and safe alternatives to chronic transfusions in select pediatric SCA patients.
  • Careful transition from chronic transfusions to hydroxyurea therapy may be feasible for a subset of patients.