Phenotype, development, and biological function of myeloid-derived suppressor cells
Yang Zhao1, Tingting Wu1, Steven Shao1
1Transplantation Biology Research Division; State Key Laboratory of Biomembrane and Membrane Biotechnology; Institute of Zoology; Chinese Academy of Sciences ; Beijing, China.
Oncoimmunology
|April 9, 2016
Summary
Myeloid-derived suppressor cells (MDSCs) are key innate immune regulators. This review details the molecular factors and pathways that control their induction, function, and immunosuppressive roles in various diseases.
Area of Science:
- Immunology
- Cell Biology
Background:
- Myeloid-derived suppressor cells (MDSCs) are innate regulatory cells crucial in diseases like cancer and autoimmune disorders.
- MDSCs comprise monocytic (M-MDSCs) and granulocytic (G-MDSCs) subtypes with distinct phenotypes.
- They significantly impact pathogenesis in cancers, chronic infections, autoimmune diseases, and transplantation.
Conclusions:
- MDSC induction and function are tightly regulated by a complex network of extracellular and intracellular signals.
- Understanding these regulatory pathways is crucial for developing therapeutic strategies targeting MDSCs in disease.
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