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Updated: Mar 22, 2026

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
Published on: June 27, 2025
The colorectal cancer immune paradox revisited
Mihaela Angelova1, Pornpimol Charoentong1, Hubert Hackl1
1Biocenter, Division of Bioinformatics, Medical University of Innsbruck Innrain 80 , Innsbruck, Austria.
Abstract:
Tumor infiltrating lymphocytes (TILs) represent a strong independent predictor of relapse and overall survival in colorectal cancer (CRC). However, it appears that a majority of CRCs, i.e., microsatellite stable (MSS) tumors, are refractory to immune checkpoint blockers. The results of recent comprehensive analyses of genomic data provide possible answers.
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