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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Published on: October 12, 2012

Clinically granulomatous cheilitis with plasma cells.

Somenath Sarkar¹, Sarmistha Ghosh¹, Dipayan Sengupta¹

¹Department of Dermatology, School of Tropical Medicine, Kolkata, West Bengal, India.

Indian Dermatology Online Journal

|April 9, 2016

Summary

Plasma cell cheilitis presents as lip inflammation, while granulomatous cheilitis causes lip swelling. A case study highlights a patient with lip swelling, diagnosed via histology as plasma cell cheilitis.

Keywords:

Cheilitis granulomatous plasma cell

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Area of Science:

Oral pathology
Dermatology
Inflammatory conditions

Background:

Plasma cell cheilitis (PCC) is a benign inflammatory condition affecting the lips, characterized by erythematous plaques.
Histopathology of PCC shows dense, band-like plasma cell infiltrates in the dermis.
Granulomatous cheilitis (GC), part of orofacial granulomatosis, presents with lip swelling, often becoming firm with recurrence.

Observation:

A 52-year-old man presented with diffuse lower lip swelling, clinically mimicking GC.
The patient's presentation involved significant edema and a firm consistency of the lower lip.

Findings:

Histopathological examination revealed a diffuse infiltrate of plasma cells.
Plasma cells were predominantly located in the upper and mid-dermis, distinguishing it from typical PCC patterns.
The findings suggest a variant presentation of plasma cell cheilitis.

Implications:

This case expands the understanding of plasma cell cheilitis presentations.
It underscores the importance of histopathology in differentiating lip inflammatory conditions.
Accurate diagnosis is crucial for appropriate management of cheilitis and orofacial granulomatosis.