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The Association between Androgenic Hormone Levels and the Risk of Developing Coronary Artery Disease (CAD)

Farzad Allameh1, Gholamreza Pourmand2, Ali Bozorgi3

  • 1Dept. of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian Journal of Public Health
|April 9, 2016
PubMed

Insights

Serum androgen levels showed no association with coronary artery disease (CAD) risk in Iranian men. Age and diabetes were the primary risk factors identified, overshadowing hormonal influences.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Coronary Artery Disease (CAD) is a significant health concern.
  • Androgens play a role in various physiological processes, but their direct link to CAD requires further investigation.

Purpose of the Study:

  • To investigate the relationship between serum androgen levels and the prevalence of Coronary Artery Disease (CAD) in an Iranian male population.

Main Methods:

  • A case-control study involving 200 CAD patients and 135 controls from Tehran Heart Center and Sina Hospital.
  • Serum levels of total testosterone, free testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), and Sex Hormone Binding Globulin (SHBG) were measured.
  • Statistical analyses included chi-square, ANOVA, and logistic regression to assess correlations.

Main Results:

  • Significant differences in age, diabetes, and hypertension history were noted between CAD and control groups.
  • Higher serum levels of free testosterone and DHEA-S were observed in the control group compared to the CAD group.
  • Logistic regression revealed age and diabetes as significant predictors of CAD, independent of androgen levels.

Conclusions:

  • Despite observed differences in some androgen levels, no direct association was found between androgenic hormones and CAD risk.
  • Age and diabetes mellitus emerged as the predominant risk factors for CAD in this cohort.
Abstract

Keywords:
Androgenic hormonesCoronary Artery Disease (CAD)DHEA-SEstradiolSHBGTestosterone

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