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Pancreatic exocrine insufficiency after pancreatic surgery
Ruediger Goess1, Güralp O Ceyhan, Helmut Friess
1Department of Surgery, Technical University of Munich, Munich, Germany - helmut.friess@tum.de.
Panminerva Medica
|April 9, 2016
Summary
Pancreatic exocrine insufficiency is a common long-term complication after pancreatic surgery. Early diagnosis and treatment are crucial for improving patient quality of life.
Area of Science:
- Gastroenterology and Surgical Oncology
Background:
- Pancreatic exocrine insufficiency (PEI) is an underestimated complication after pancreatectomy.
- Focus is shifting to long-term complications, including PEI, impacting quality of life.
Purpose of the Study:
- To review the pathophysiology, diagnosis, risk factors, and treatment of PEI post-pancreatectomy.
- To highlight the challenges in diagnosing and managing PEI, especially after pancreaticoduodenectomy.
Main Methods:
- Literature review summarizing current knowledge on PEI following pancreatic surgery.
- Focus on patients undergoing pancreaticoduodenectomy, pylorus-preserving pancreaticoduodenectomy, or distal pancreatectomy.
Main Results:
- PEI incidence depends on diagnosis, preoperative function, and resection extent.
- Diagnosis is challenging, often relying on symptoms rather than objective tests.
- Enzyme replacement therapy is the primary treatment, though evidence from controlled trials is limited.
Conclusions:
- Pancreatic exocrine function is vital for postsurgical patient well-being.
- Further clinical trials are needed to optimize PEI management after different pancreatic resections.
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