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Updated: Mar 22, 2026
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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
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Association between thromboxane A2 receptor polymorphisms and asthma risk: A meta-analysis
Yilin Pan1, Shaojun Li1, Xinming Xie1
1a Department of Respiratory Medicine , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi , China.
Summary
This meta-analysis found a link between thromboxane A2 receptor (TBXA2R) +924C/T gene variations and asthma risk. The TBXA2R +795C/T polymorphism may also be a risk factor for aspirin-intolerant asthma (AIA).
Area of Science:
- Genetics
- Pulmonology
- Pharmacogenomics
Background:
- Asthma is a complex respiratory disease influenced by genetic factors.
- Thromboxane A2 receptor (TBXA2R) gene polymorphisms have been investigated for their potential role in asthma susceptibility.
- Understanding these genetic associations can inform personalized medicine approaches for asthma management.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between TBXA2R gene polymorphisms (+924C/T and +795C/T) and asthma risk.
- To investigate potential links between these polymorphisms and specific asthma subphenotypes, such as atopic asthma and aspirin-intolerant asthma (AIA).
Main Methods:
- A systematic literature search was performed across major databases (PubMed, Embase, CNKI, Wanfang) updated to May 1, 2015.
- Included studies focused on the association between TBXA2R gene polymorphisms and asthma risk.
- Meta-analysis techniques were employed to pool data from 7 studies for +924C/T and 6 studies for +795C/T polymorphisms.
Main Results:
- A significant association was found between the TBXA2R +924C/T polymorphism and overall asthma risk in the recessive model (OR = 1.33, P = 0.045).
- The TBXA2R +795C/T polymorphism showed a significant association with aspirin-intolerant asthma (AIA) risk in both allelic (OR = 1.30, P = 0.014) and dominant (OR = 1.50, P = 0.008) models.
- Subgroup analysis revealed a significant association between TBXA2R +924C/T and atopic asthma risk (recessive model, OR = 1.43, P = 0.043), but not in Asian populations.
Conclusions:
- The TBXA2R +924C/T polymorphism is associated with an increased risk of asthma.
- The TBXA2R +795C/T polymorphism may serve as a risk factor for aspirin-intolerant asthma (AIA).
- Further large-scale, well-designed studies are warranted to confirm these genetic associations.
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