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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Published on: April 12, 2019

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Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma

Atik Badshah Shaikh1, Fangfei Li2, Min Li3,4

  • 1Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. aatikshaikh@gmail.com.

International Journal of Molecular Sciences
|April 9, 2016
PubMed

Insights

Novel therapies targeting osteosarcoma (OS) are crucial, especially for metastatic cases. This review explores molecular targets and drug delivery systems to improve outcomes for this pediatric bone cancer.

Area of Science:

  • Oncology
  • Biomedical Research
  • Pediatric Cancer

Background:

  • Osteosarcoma (OS) is a primary bone cancer predominantly affecting the pediatric population.
  • Current treatments (surgery, chemotherapy) achieve 60%-75% cure rates for primary OS, but only 15%-30% for metastatic or relapsed cases.

Purpose of the Study:

  • To review current molecular mechanisms and therapeutic targets for osteosarcoma.
  • To summarize updated clinical trial information on OS-targeting therapies.
  • To discuss novel therapeutic targets and drug delivery systems for osteosarcoma.

Main Methods:

  • Literature review of molecular mechanisms in osteosarcoma.
  • Analysis of current therapeutic strategies and clinical trials.
  • Exploration of novel targets and drug delivery systems.

Main Results:

  • Identified key molecular mechanisms and targets in osteosarcoma development.
  • Compiled updated information on ongoing clinical trials for OS therapies.
  • Highlighted potential novel therapeutic targets and advanced drug delivery systems.

Conclusions:

  • A comprehensive understanding of osteosarcoma pathogenesis is essential.
  • Targeted therapies and innovative drug delivery systems offer promise for improving outcomes, particularly in metastatic osteosarcoma.
Keywords:
molecular mechanismmolecular targetsosteosarcomatargeted therapy

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