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Development of a Microforce Sensor and Its Array Platform for Robotic Cell Microinjection Force Measurement.

Yu Xie1, Yunlei Zhou2, Yuzi Lin3

  • 1Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China. xieyu@xmu.edu.cn.

Sensors (Basel, Switzerland)
|April 9, 2016
PubMed
Summary

Researchers developed a novel micro-force sensor for robot-assisted cell microinjection. This sensor overcomes limitations of conventional methods, enabling precise, real-time force measurement for improved robotic manipulation of cells.

Keywords:
PVDF filmcell-holding devicecellular force sensorforce measurementmicroinjectionmicromanipulation

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Area of Science:

  • Robotics
  • Biotechnology
  • Materials Science

Background:

  • Robot-assisted cell microinjection offers precision and high throughput.
  • Conventional microforce sensors face real-time measurement limitations, hindering robotic integration.
  • A novel sensor is needed to address these challenges in robotic cell manipulation.

Purpose of the Study:

  • To develop a novel supported-beam based micro-force sensor for real-time force measurement during robotic cell microinjection.
  • To derive theoretical mechanical and electrical models for the sensor's function.
  • To demonstrate the sensor's effectiveness in robotic cell manipulation systems.

Main Methods:

  • Designed a supported-beam based sensor using a piezoelectric polyvinylidine fluoride film.
  • Developed theoretical mechanical and electrical models for sensor operation.
  • Micro-fabricated an array-based cell-holding device with a trapezoidal microstructure.
  • Conducted robot-assisted zebrafish embryo microinjection experiments.

Main Results:

  • The novel sensor demonstrated good repeatability and 1.82% linearity.
  • The integrated cell-holding device improved force sensing speed and cell manipulation rates.
  • Experiments confirmed the sensor's effectiveness within a robotic cell manipulation system.

Conclusions:

  • The developed micro-force sensor effectively addresses real-time force-sensing challenges in robotic microinjection.
  • The sensor's design and fabrication methods are scalable for manipulating various cell types, including mouse oocytes.
  • This technology enhances the precision and efficiency of robot-assisted cell microinjection.