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Updated: Mar 22, 2026
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Diagnosis of Choroidal Melanoma in Dense Asteroid Hyalosis
Meghna V Motiani1, Colin A McCannel1, Robert Almanzor1
1a Ophthalmic Oncology Center, Jules Stein Eye Institute, Department of Ophthalmology , University of California, Los Angeles (UCLA) , Los Angeles , CA , USA.
Purpose:
To demonstrate the utility of Optos ultra-wide field imaging in the diagnosis and management of choroidal melanoma in the setting of asteroid hyalosis.
Design:
Observational case report.
Method:
A 52-year-old female was referred for evaluation of floaters, photopsias, and blurry vision in the right eye. Clinical examination revealed dense asteroid hyalosis obscuring the fundus, and a limited view of a pigmented choroidal lesion in the nasal periphery. Optos ultra-wide field fluorescein angiography and ultrasonography facilitated the diagnosis of a choroidal melanoma.
Results:
The patient underwent Iodine-125 brachytherapy for local tumor control and excellent tumor response was confirmed with serial follow-up Optos imaging and ultrasonography.
Conclusion:
Ultra-wide field fundus fluorescein angiography facilitated the diagnosis of a choroidal melanoma, which was obscured by dense asteroid hyalosis, allowing for local tumor control with brachytherapy. Optos wide-field imaging may be a valuable tool for detecting potentially life-threatening lesions in the setting of asteroid hyalosis.
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