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Working Memory

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...

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Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Published on: August 14, 2015

Aβ1-42-induced dysfunction in synchronized gamma oscillation during working memory.

Wenwen Bai¹, Mi Xia¹, Tiaotiao Liu¹

¹School of Biomedical Engineering, Tianjin Medical University, Tianjin, 300070, China.

Behavioural Brain Research

|April 9, 2016

Summary

This summary is machine-generated.

Amyloid-beta peptide (Aβ) impairs working memory in rats by disrupting synchronized gamma oscillations in the medial prefrontal cortex. This suggests a key mechanism underlying Alzheimer's disease cognitive deficits.

Keywords:

Amyloid-β peptide Gamma oscillation Local field potential (LFP)Rat Spike Working memory

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Last Updated: Mar 22, 2026

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Published on: August 14, 2015

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG

Published on: March 10, 2017

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Area of Science:

Neuroscience
Cognitive Science
Pathophysiology of Alzheimer's Disease

Background:

Amyloid-beta peptide (Aβ) is a known contributor to cognitive impairments in Alzheimer's disease (AD).
Neuronal oscillations, particularly synchronized gamma oscillations, are crucial for working memory function.
The impact of Aβ on neuronal oscillations and working memory remains under-investigated.

Purpose of the Study:

To investigate the effects of Aβ on neuronal oscillations and working memory.
To explore the role of gamma synchronization in Aβ-induced cognitive deficits.

Main Methods:

Rats were trained on a Y-maze delay-alternation task.
Spike trains and local field potentials (LFPs) were recorded from the medial prefrontal cortex (mPFC).
Gamma synchronization was assessed using phase locking between spike trains and LFPs.

Main Results:

Aβ-injected rats exhibited significant working memory impairment compared to controls.
In control rats, gamma synchronization preceded correct choices during memory retention.
Aβ-injected rats showed no change in gamma synchronization during either correct or error trials.

Conclusions:

Aβ1-42 induces working memory deficits.
Dysfunction in gamma synchronization is a potential mechanism for Aβ-induced working memory impairment in Alzheimer's disease.