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Expanded endoscopic endonasal surgery for advanced stage juvenile angiofibromas: a retrospective multi-center study
C Langdon1, P Herman2, B Verillaud2
1Department of Otolaryngology, Hospital Clinic, University of Barcelona Medical School, Barcelona, Spain.
Rhinology
|April 10, 2016
Summary
Expanded endonasal endoscopic approaches are a feasible option for advanced juvenile nasopharyngeal angiofibromas (JNA). This study shows good long-term results for JNA patients treated with this minimally invasive technique.
Area of Science:
- Otolaryngology
- Neurosurgery
- Surgical Oncology
Background:
- Juvenile nasopharyngeal angiofibromas (JNA) are rare benign tumors.
- Endoscopic resection is standard for most JNA cases.
- Intracranial extension presents surgical challenges.
Purpose of the Study:
- To evaluate the efficacy of expanded endonasal endoscopic approaches for advanced stage JNA.
- To assess outcomes including blood loss, hospital stay, and recurrence rates.
- To analyze factors influencing residual disease.
Main Methods:
- Retrospective multicenter study of 74 male patients with Radkowski stage IIIA or IIIB JNA.
- Data collected from five academic ORL-HNS departments.
- Key outcomes: intraoperative blood loss, hospital stay, complications, persistence/recurrence.
Main Results:
- Mean age 16.4 years; 71 patients had preoperative embolization.
- Mean blood loss was 1279.7 ml; higher blood loss correlated with more involved subsites.
- Residual disease linked to extensive subsite involvement; all patients asymptomatic at follow-up.
Conclusions:
- Expanded endonasal endoscopic approaches are feasible for advanced JNA.
- This technique offers good long-term results for complex JNA cases.
- Minimally invasive surgery can effectively manage JNA with intracranial extension.
