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Related Concept Videos

Human Virome01:26

Human Virome

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The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...
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Viral Mutations00:36

Viral Mutations

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus
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Recent advances in human viruses imaging studies.

Paula Ecaterina Florian1, Yves Rouillé2, Simona Ruta3

  • 1Department of , Ligand-Receptor Interactions, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.

Journal of Basic Microbiology
|April 10, 2016
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Advanced microscopy techniques, including super-resolution and electron microscopy, offer new insights into human virus life cycles. These imaging tools aid in understanding viral pathogenesis and developing diagnostics and therapeutics.

Keywords:
Electron microscopyFluorescence microscopyHuman virusesSuper-resolution

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Area of Science:

  • Virology
  • Microscopy
  • Pathogenesis

Background:

  • Microscopy is crucial for studying viral life cycles, including host cell interactions and virion release.
  • Fluorescence microscopy tracks viral infections and pathogen-host interactions.
  • Super-resolution and electron microscopy overcome limitations of conventional methods, revealing viral formation and ultrastructure.

Purpose of the Study:

  • To review recent advances in human virus imaging.
  • To highlight the application of novel imaging technologies in both in vitro and in vivo models.
  • To emphasize the contribution of imaging to understanding viral pathogenesis.

Main Methods:

  • Review of recent literature on advanced microscopy techniques for human virus imaging.
  • Focus on super-resolution microscopy and state-of-the-art electron microscopy.
  • Inclusion of studies using in vitro cell cultures and in vivo animal models.

Main Results:

  • Super-resolution microscopy provides novel insights into human virus formation and trafficking.
  • Electron microscopy reveals groundbreaking ultrastructural details of virus morphogenesis.
  • Advanced imaging technologies enhance understanding of viral pathogenesis in various models.

Conclusions:

  • Novel imaging technologies significantly advance the understanding of human virus pathogenesis.
  • These techniques are vital for early diagnosis of viral infections.
  • Advanced microscopy will be instrumental in developing new antiviral therapeutics.