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Related Concept Videos

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Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
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GnRH agonist triggering affects the kinetics of embryo development: a comparative study.

Ali Sami Gurbuz1, Funda Gode2, Mehmet Sukru Uzman3

  • 1Novafertil IVF Centre, Yeni Meram yolu No:75, Meram, Konya, Turkey. alisamigurbuz@hotmail.com.

Journal of Ovarian Research
|April 10, 2016
PubMed
Summary

Gonadotropin-releasing hormone agonists (GnRHa) accelerate early embryo development compared to human chorionic gonadotropin (hCG) in in vitro fertilization cycles, as shown by time-lapse imaging.

Keywords:
Agonist triggerEmbryo qualityMorphokineticOocyteTime lapse

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Area of Science:

  • Reproductive Endocrinology
  • Embryology
  • In Vitro Fertilization

Background:

  • Ovulation induction is critical in assisted reproductive technologies.
  • Human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone agonists (GnRHa) are commonly used as ovulation triggers.
  • The impact of different triggers on early embryo development requires detailed evaluation.

Purpose of the Study:

  • To compare the effects of GnRHa versus hCG on in vitro early embryo development.
  • To analyze embryo kinetics using time-lapse imaging.

Main Methods:

  • Retrospective analysis of prospectively collected data from 152 infertile couples undergoing intracytoplasmic sperm injection.
  • Embryo culture and monitoring in a time-lapse incubator (EmbryoScope).
  • Evaluation of embryo morphokinetic parameters.

Main Results:

  • A total of 739 embryos were analyzed: 252 from GnRHa-triggered cycles and 487 from hCG-triggered cycles.
  • Embryos from GnRHa-triggered cycles exhibited significantly faster cleavage rates compared to those from hCG-triggered cycles.
  • Time-lapse analysis provided detailed insights into embryo kinetics differences.

Conclusions:

  • Ovulation triggering with GnRHa influences early embryo development kinetics in IVF cycles.
  • GnRHa may offer advantages in promoting faster embryo development compared to hCG.
  • Further research can explore the clinical implications of these kinetic differences.