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GnRH agonist triggering affects the kinetics of embryo development: a comparative study
Ali Sami Gurbuz1, Funda Gode2, Mehmet Sukru Uzman3
1Novafertil IVF Centre, Yeni Meram yolu No:75, Meram, Konya, Turkey. alisamigurbuz@hotmail.com.
Background:
To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system.
Methods:
Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles.
Interventions:
Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Göteborg, Sweden).
Main Outcome Measures:
Embryo morphokinetic parameters.
Results:
In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles.
Conclusion:
Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics.
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