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Regulation of 5-methyltetrahydrofolate synthesis
M Lumb1, T Bottiglieri, R Deacon
1Haematology Section, M.R.C. Clinical Research Centre, Northwick Park Hospital, Harrow, Middx., U.K.
The Biochemical Journal
|March 1, 1989
Abstract:
After an intraperitoneal injection of 100 mumol of methionine to rats, there is rapid oxidation of the methyl group of hepatic 5-methyltetrahydrofolate to formate and CO2. Recovery of the methylfolate level starts 2.5 h after the methionine injection, when the hepatic methionine level and the S-adenosylmethionine/S-adenosylhomocysteine ratio have returned to baseline values. S-Adenosylmethionine concentration is still elevated at this time.