Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

Published on: August 6, 2020

Studying human disease using human neurons.

Tim Ahfeldt¹, Nadia K Litterman¹, Lee L Rubin¹

¹Department of Stem Cells and Regenerative Biology, Harvard University, Cambridge, MA, USA.

|April 10, 2016

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity.

bioRxiv : the preprint server for biology·2026

Same author

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy.

Frontiers in neuroscience·2026

Same author

Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy.

Muscle & nerve·2026

Same author

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy.

bioRxiv : the preprint server for biology·2025

Same author

Activated GDF11/8 subforms predict cardiovascular events and mortality in humans.

Nature communications·2025

Same author

Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockout.

iScience·2025

Same journal

IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

Brain research·2026

Same journal

Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

Brain research·2026

Same journal

Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

Brain research·2026

Same journal

Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

Brain research·2026

Same journal

Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

Brain research·2026

Same journal

Emotions, the amygdala, and the right hemisphere.

Brain research·2026

See all related articles

Patient-derived human stem cell neurons offer a powerful new approach for discovering drugs targeting nervous system diseases. This method enhances therapeutic assessment and disease mechanism studies, overcoming traditional challenges.

Area of Science:

Neuroscience
Pharmacology
Stem Cell Biology

Background:

Drug discovery for neurological disorders faces significant challenges.
Traditional methods have limitations in modeling complex human nervous system diseases.
Patient-derived cells offer a promising avenue for personalized medicine and disease modeling.

Purpose of the Study:

To review the potential of human stem cell-derived neuron models for drug discovery and high-throughput screening.
To compare these novel strategies with traditional drug discovery approaches.
To discuss considerations and future directions for stem cell-based assays in neurological research.

Main Methods:

Review of current literature on human stem cell-derived neuron models.
Comparison of stem cell-based drug screening with conventional methods.

Keywords:

Drug discovery Human neurodegenerative disease Stem cells

More Related Videos

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor

Published on: March 17, 2023

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

Published on: April 14, 2013

Related Experiment Videos

Last Updated: Mar 22, 2026

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

Published on: August 6, 2020

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor

Published on: March 17, 2023

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

Published on: April 14, 2013

Discussion of enabling technologies like genome editing.

Main Results:

Human stem cell-derived neurons show significant promise for therapeutic assessment and high-throughput screening.
These models offer advantages over traditional strategies for neurological disease drug discovery.
Recent successes highlight the viability and potential of this approach.

Conclusions:

Human stem cell-derived neurons represent a valuable tool for advancing neurological drug discovery.
These models facilitate personalized medicine by enabling pre-clinical efficacy and safety testing.
Further development and integration of new technologies will overcome remaining challenges in the field.