Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

5.1K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stakeholder perspectives on potential open-label bias in patient-reported outcome results from cancer clinical trials: evidence from the IMPROvE project.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2026
Same author

Prognostic value for overall survival of the EORTC QLQ-C30 Summary Score: An analysis of 5 closed EORTC trials.

European journal of cancer (Oxford, England : 1990)·2026
Same author

From reliability to implementable toxicity policy in PRO-informed CTCAE - Authors' reply.

The Lancet. Oncology·2026
Same author

Detection and Phylogenetic Characterization of Canine Distemper Virus from a Red Fox in Hungary.

Viruses·2026
Same author

The EORTC updated breast cancer quality of life questionnaire EORTC QLQ-BR42: A psychometric study with Spanish patients.

BMC cancer·2026
Same author

Assessment of multimodal inpatient treatment in psychosomatic medicine using patient reported outcomes: A naturalistic and longitudinal data analysis.

Journal of affective disorders·2026

Related Experiment Video

Updated: Mar 22, 2026

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.2K

Osteoprotegerin Levels Decrease in Abstinent Alcohol-Dependent Patients.

Peter Malik1, Gabriele von Gleissenthall1, Rudolf W Gasser2

  • 1Department of Psychiatry & Psychotherapy, Medical University of Innsbruck, Innsbruck, Austria.

Alcoholism, Clinical and Experimental Research
|April 11, 2016
PubMed
Summary
This summary is machine-generated.

Eight weeks of abstinence in alcohol-dependent patients led to decreased osteoprotegerin (OPG) and increased bone formation markers, suggesting reversible bone mineral density (BMD) loss. Inflammatory markers also reduced, indicating their role in alcohol-related bone metabolism issues.

Keywords:
Alcohol DependenceBone Mineral DensityOsteocalcinOsteoprotegerinReceptor Activator of the Nuclear Factor-κB Ligand

More Related Videos

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

846
Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
10:00

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells

Published on: December 11, 2020

3.1K

Related Experiment Videos

Last Updated: Mar 22, 2026

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.2K
Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

846
Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
10:00

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells

Published on: December 11, 2020

3.1K

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Alcohol-Related Disorders

Background:

  • Osteoprotegerin (OPG) is linked to reduced bone mineral density (BMD) and is elevated in alcohol-dependent individuals.
  • Alcohol dependence is associated with increased OPG levels and potential bone metabolism disturbances.
  • Understanding OPG and RANKL dynamics during abstinence is crucial for managing BMD in alcohol-dependent patients.

Purpose of the Study:

  • To investigate changes in OPG and RANKL levels during an 8-week abstinence period in alcohol-dependent patients.
  • To assess the influence of alcohol-related variables, smoking, and physical activity on BMD and OPG/RANKL levels.
  • To explore the relationship between abstinence, bone metabolism markers, and inflammatory parameters.

Main Methods:

  • Study included 43 alcohol-dependent patients with less than one week of abstinence.
  • OPG, RANKL, and other bone metabolism markers were measured at baseline and after 8 weeks.
  • Bone mineral density (BMD) was measured once post-treatment; inflammatory parameters were also assessed.

Main Results:

  • Significant decrease in OPG levels and a significant increase in osteocalcin (bone formation marker) observed.
  • No significant changes in RANKL, RANKL/OPG ratio, Serum CrossLaps, or hormones were found.
  • Significant reduction in inflammatory parameters after 8 weeks of abstinence; no confounding influence of alcohol-related variables detected.

Conclusions:

  • Abstinence may reverse reduced BMD in alcohol-dependent patients through enhanced bone formation.
  • Inflammatory processes are confirmed to play a role in alcohol-induced bone metabolism disturbances.
  • OPG levels decrease with abstinence, potentially indicating a recovery of bone metabolism.