Related Experiment Video
Updated: Mar 22, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
Published on: October 24, 2025
Understanding Protein-Protein Interactions: Essential Players in (Patho)physiology (Part 2)
Andrew J Wilson1,2, Patrick T Gunning3,4
1School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. a.j.wilson@leeds.ac.uk.
This special issue explores protein-protein interactions as therapeutic targets. It highlights novel strategies for intervening in these crucial biological processes for drug development.
Area of Science:
- Medicinal Chemistry
- Chemical Biology
- Drug Discovery
Background:
- Protein-protein interactions (PPIs) are central to cellular functions.
- Dysregulated PPIs are implicated in numerous diseases, making them attractive therapeutic targets.
Discussion:
- This collection focuses on targeting PPIs for therapeutic intervention.
- Articles showcase innovative chemical and biological strategies to modulate PPIs.
Key Insights:
- Novel small molecules and biologics are being developed to disrupt disease-causing PPIs.
- Understanding PPI interfaces is crucial for designing effective therapeutics.
Outlook:
- Future research will likely focus on refining PPI-targeting drugs.
- Expanding the scope of PPIs as druggable targets remains a key goal.
More Related Videos
07:57Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
09:39Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
Published on: March 31, 2022
Related Concept Videos
Protein-protein Interfaces
Protein-Protein Interfaces
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks
Protein-Drug Binding: Mechanism and Kinetics
Various forces drive these interactions, including hydrogen bonds, hydrophobic interactions, ionic bonds, electrostatic interactions, and van der Waals forces. These bonds enable drugs to bind to specific sites on proteins,...
Factors Affecting Protein-Drug Binding: Drug Interactions
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...