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Effect of oral activated charcoal on quinine elimination
1Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne.
British Journal of Clinical Pharmacology
|January 1, 1989
Abstract:
The effect of repeated dose oral activated charcoal on quinine elimination has been studied following a therapeutic (600 mg) dose of quinine bisulphate to seven normal volunteers. Activated charcoal lowered quinine half-life from 8.23 +/- 0.57 s.d. h to 4.55 +/- 0.15 s.d. h (P less than 0.001) and increased its oral clearance by 56%. Activated charcoal may have a role in the management of quinine poisoning.