Related Experiment Video
Updated: Mar 22, 2026
09:34
Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
Published on: May 18, 2017
8.0K
Membrane-based Therapeutic Plasma Exchange: A New Frontier for Nephrologists
1Section of Nephrology, Department of Medicine, Rush University Medical Center, Chicago, Illinois. casey_gashti@rush.edu.
Seminars in Dialysis
|April 11, 2016
Summary
Therapeutic plasma exchange removes harmful substances from blood. Membrane-based separation, increasingly used by nephrologists, offers a safer, adaptable alternative to centrifuge methods for immune-mediated diseases.
Area of Science:
- Nephrology
- Immunology
- Biomedical Engineering
Background:
- Therapeutic plasma exchange (TPE) is a crucial treatment for immune-mediated diseases.
- TPE removes pathogenic substances from plasma, replacing it with fluid.
- Two main separation methods exist: centrifuge and membrane-based.
Purpose of the Study:
- To detail membrane-based plasma separation techniques.
- To guide TPE prescription for nephrologists.
- To compare membrane separation with centrifuge methods.
Main Methods:
- Review of membrane technology in TPE.
- Analysis of TPE prescription parameters.
- Comparative assessment of separation methodologies.
Main Results:
- Membrane technology advancements enhance biocompatibility and safety.
- Membrane-based TPE integrates with standard dialysis/hemofiltration equipment.
- Nephrologists are increasingly involved due to familiarity with extracorporeal systems.
Conclusions:
- Membrane-based plasma separation is a key advancement in TPE.
- This technique offers advantages in safety and adaptability.
- Nephrologists play a vital role in its application for immune-mediated diseases.
Related Concept Videos
01:30Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
799
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
799
01:25Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
326
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
326
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
336
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
336
01:20Acute Kidney Injury V: Interprofessional Care
453
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
453
01:24Hemodialysis II: Procedure and Complications
1.7K
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.7K
01:30Continuous Renal Replacement Therapy
1.8K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.8K