Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.5K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.5K
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

208
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
208

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rasch validation of the Keratoconus End-Points Assessment Questionnaire in a Spanish population with keratoconus.

Archivos de la Sociedad Espanola de Oftalmologia·2024
Same author

Evaluating the QileX-RhE skin corrosion test for chemical subcategorization in accordance with OECD TG 431.

Toxicology in vitro : an international journal published in association with BIBRA·2024
Same author

An effective method for culturing functional human corneal endothelial cells using a xenogeneic free culture medium.

Scientific reports·2023
Same author

Progress in the use of plasma rich in growth factors in ophthalmology: from ocular surface to ocular fundus.

Expert opinion on biological therapy·2021
Same author

Xeno-free approach for the expansion of human adipose derived mesenchymal stem cells for ocular therapies.

Experimental eye research·2020
Same author

Review of the evidence on handling drugs and hazardous products in Urology Departments. Consensus document between the Spanish Urological Association and the Spanish Society of Hospital Pharmacy.

Actas urologicas espanolas·2018
Same journal

Extra-ocular muscle haematoma masquerading uveal prolapse post blunt trauma to the eye: A case report.

Archivos de la Sociedad Espanola de Oftalmologia·2026
Same journal

Multifocal intraocular lenses in refractive lens exchange: Guidelines to optimize their use and indications.

Archivos de la Sociedad Espanola de Oftalmologia·2026
Same journal

The effect of pre- and perioperative anxiety on cardiovascular parameters and intraocular pressure of patients awaiting phacoemulsification surgery.

Archivos de la Sociedad Espanola de Oftalmologia·2026
Same journal

Management of central corneal opacities using manual and femtosecond laser-assisted rotational anterior lamellar autokeratoplasty: A descriptive case series.

Archivos de la Sociedad Espanola de Oftalmologia·2026
Same journal

Evaluation of the anterior hyaloid using intraoperative optical coherence tomography: a key strategy in complex cataract surgery.

Archivos de la Sociedad Espanola de Oftalmologia·2026
Same journal

Unilateral ocular hypertension secondary to frontal mucocele with orbital extension.

Archivos de la Sociedad Espanola de Oftalmologia·2026
See all related articles

Related Experiment Video

Updated: Mar 22, 2026

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
05:57

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Published on: August 2, 2022

5.2K

Platelet rich plasma in ocular surface.

A C Riestra1, J M Alonso-Herreros2, J Merayo-Lloves1

  • 1Instituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, Oviedo, España.

Archivos De La Sociedad Espanola De Oftalmologia
|April 11, 2016
PubMed
Summary
This summary is machine-generated.

Platelet-rich plasma (PRP) shows promise for ocular surface diseases like dry eye. While safe and effective, optimal preparation methods and growth factor concentrations require further research.

Keywords:
Blood productsCorneaCórneaDerivados hemáticosOcular surfacePlasma rich in growth factorsPlasma rico en factores de crecimientoPlasma rico en plaquetasPlatelet rich plasmaSuperficie ocular

More Related Videos

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
14:38

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

19.6K
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

3.1K

Related Experiment Videos

Last Updated: Mar 22, 2026

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
05:57

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Published on: August 2, 2022

5.2K
Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
14:38

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

19.6K
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

3.1K

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Platelet-rich preparations are increasingly used for tissue repair and regeneration.
  • These therapies leverage the role of platelet-derived growth factors in healing processes.

Purpose of the Study:

  • To review the evidence on using plasma rich in growth factors (PRGF) on the ocular surface.
  • To analyze the effects of growth factors, preparation methods, and safety/efficacy data for ocular surface diseases.

Main Methods:

  • Systematic literature review of studies on PRGF applications in ophthalmology.
  • Analysis of preparation techniques and their impact on growth factor concentration.
  • Evaluation of clinical outcomes and safety profiles in treated ocular surface conditions.

Main Results:

  • PRGF preparations have demonstrated good safety and efficacy in treating ocular surface diseases such as dry eye and persistent epithelial defects.
  • Significant variation exists in preparation methods and resulting growth factor concentrations across different systems.
  • No consensus has been reached on the optimal method for preparing these therapeutic agents.

Conclusions:

  • Platelet-rich plasma is a viable therapeutic option for various ocular surface diseases.
  • Further comparative studies are necessary to establish optimal preparation protocols and compare PRGF efficacy against existing treatments.
  • Standardization of preparation methods is crucial for consistent clinical outcomes.