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Related Experiment Video

Updated: Mar 22, 2026

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EVALUATION OF QUANTITATIVE THYROID SCINTIGRAPHY FOR DIAGNOSIS AND STAGING OF DISEASE SEVERITY IN CATS WITH

Mark E Peterson1,2, Jade N Guterl1, Mark Rishniw2

  • 1Animal Endocrine Clinic, New York, NY, 10025.

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
|April 11, 2016
PubMed
Summary

Thyroid scintigraphy using percent thyroidal uptake of 99mTcO4 (TcTU) is an accurate diagnostic test for feline hyperthyroidism. TcTU best predicts the functional volume and metabolic activity of the feline thyroid gland.

Keywords:
catfelinehyperthyroidismscintigraphythyroid gland

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Area of Science:

  • Veterinary Nuclear Medicine
  • Diagnostic Imaging in Feline Medicine

Background:

  • Feline hyperthyroidism is commonly diagnosed using thyroid scintigraphy.
  • The thyroid-to-salivary (T/S) ratio is the standard quantitative measure, but other indices like percent thyroidal uptake of 99mTcO4 (TcTU) are less explored.

Purpose of the Study:

  • To prospectively evaluate multiple quantitative scintigraphic indices for diagnosing feline hyperthyroidism.
  • To compare the diagnostic accuracy and correlation of T/S ratio, thyroid-to-background (T/B) ratios, and TcTU with clinical and biochemical parameters.

Main Methods:

  • A prospective, cross-sectional study involving 524 cats with suspected hyperthyroidism.
  • Quantitative scintigraphic indices including T/S, three T/B ratios, and TcTU were calculated.
  • Diagnosis was confirmed via serum thyroid panel (T4, T3, fT4, TSH).

Main Results:

  • Median TcTU, T/S, and T/B ratios were significantly higher in hyperthyroid cats (P < 0.001).
  • All parameters showed good sensitivity and specificity, with T/S ratio having the highest test accuracy.
  • TcTU demonstrated stronger correlations with serum T4, T3, and estimated thyroid volume compared to T/S ratio.

Conclusions:

  • Percent thyroidal uptake of 99mTcO4 (TcTU) is an accurate diagnostic test for feline hyperthyroidism.
  • TcTU is the superior parameter for predicting functional thyroid volume and metabolic activity in cats with adenomatous thyroid disease.