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Medicinal Plants with Antiplatelet Activity.

Mohammed El Haouari1,2, Juan A Rosado3

  • 1Centre Régional des Métiers de l'Education et de la Formation de Taza (CRMEF - Taza), B.P. 1178, Taza Gare, Morocco.

Phytotherapy Research : PTR
|April 11, 2016
PubMed
Summary

Medicinal plants show potent antiplatelet activity by interfering with platelet signaling pathways. These natural compounds offer a promising avenue for developing safer agents to prevent cardiovascular diseases and thromboembolic disorders.

Keywords:
antiplatelet activitycardiovascular diseasesmedicinal plantsplatelets

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Cardiovascular Medicine

Background:

  • Blood platelets are crucial for hemostasis and wound healing.
  • Platelet hyperactivity contributes to cardiovascular diseases and complications.
  • There is a significant need for potent and safe antiplatelet agents.

Purpose of the Study:

  • To review experimental studies on medicinal plants with antiplatelet activity.
  • To identify bioactive constituents, plant parts used, and modulated signaling pathways.
  • To explore the potential of medicinal plants in developing novel antiplatelet therapies.

Main Methods:

  • Literature review of experimental studies on medicinal plants.
  • Analysis of bioactive constituents and their antiplatelet mechanisms.
  • Examination of affected platelet signaling pathways.

Main Results:

  • Medicinal plants from families like Asteraceae, Rutaceae, and Lamiaceae exhibit antiplatelet effects.
  • Bioactive compounds include polyphenols, flavonoids, coumarins, and terpenoids.
  • Mechanisms involve inhibiting ADP, TXA2, Ca(2+) mobilization, and phosphoinositide breakdown.

Conclusions:

  • Medicinal plants possess significant antiplatelet potential.
  • Understanding constituents and mechanisms can lead to new antiplatelet drugs.
  • These agents could prevent thromboembolic disorders by inhibiting platelet aggregation.