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Ocular absorption of benzydamine by the rabbit
B Catanese1, P Valeri, A Lagana
1F. Angelini Research Institute, Rome, Italy.
Biopharmaceutics & Drug Disposition
|March 1, 1989
Summary
Benzydamine hydrochloride, a non-steroidal anti-inflammatory drug, was applied to rabbit eyes. The drug reached ocular tissues but not plasma, suggesting potential for localized eye inflammation treatment with minimal systemic side effects.
Area of Science:
- Ophthalmology
- Pharmacology
- Drug Delivery
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are crucial for managing ocular inflammation.
- Systemic absorption of ocular drugs can lead to unwanted side effects.
- Benzydamine hydrochloride is an NSAID with potential anti-inflammatory properties.
Purpose of the Study:
- To evaluate the ocular and systemic distribution of benzydamine hydrochloride after topical application.
- To assess the potential of benzydamine hydrochloride for localized treatment of eye inflammation.
Main Methods:
- An aqueous solution of 0.15% benzydamine hydrochloride was topically applied to rabbit corneas.
- Drug concentrations were measured in aqueous humor and plasma following application.
Main Results:
- Benzydamine hydrochloride was detected in the aqueous humor of the treated eye shortly after topical administration.
- Plasma levels of benzydamine hydrochloride remained negligible, indicating minimal systemic absorption.
Conclusions:
- Topical ocular application of benzydamine hydrochloride leads to localized drug presence in the eye.
- The drug's pharmacokinetic profile suggests a favorable risk-benefit ratio for treating ocular inflammatory conditions.
- Benzydamine hydrochloride may offer a targeted approach to managing eye inflammation with reduced systemic exposure.