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Onychomycosis and its Chemotherapy
Anwer Basha, Fatima Basha1, Syed K Ali
1HEJ Research Institute of chemistry, Karachi university, Karachi, Pakistan. bashafz@gmail.com.
Onychomycosis, or fungal nail infections, are common but hard to treat. Difficulty in drug penetration to the infection site hinders effective cure, despite new medications.
Area of Science:
- Mycology
- Dermatology
- Pharmacology
Background:
- Onychomycosis is a prevalent global fungal infection affecting nails.
- While not typically life-threatening, it presents significant treatment challenges.
Purpose of the Study:
- To review the nature of onychomycosis.
- To discuss causative fungi and their characteristics.
- To examine the properties of drugs used for treatment.
Main Methods:
- Literature review of onychomycosis.
- Analysis of drug penetration challenges.
- Discussion of treatment characteristics.
Main Results:
- Fungal nail infections are widespread globally.
- Current treatments struggle with drug delivery to the infection site.
- Therapeutic drug concentrations are difficult to achieve.
Conclusions:
- Onychomycosis treatment is hampered by poor drug penetration.
- Understanding drug characteristics is key to improving efficacy.
- Further research into drug delivery is warranted.
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