Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

20
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
20
Anthelminthic Agents01:15

Anthelminthic Agents

33
Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
33
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

2.0K
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
2.0K
Hand hygiene01:23

Hand hygiene

6.5K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
6.5K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.5K
1.5K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of a dimeric isopimarane derivative by reexploring a labdane-related diterpenoid biosynthetic gene cluster in Aspergillus nidulans.

Microbial cell factories·2026
Same author

CsdA-LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Total Synthesis of Daphnepapytone A.

The Journal of organic chemistry·2025
Same author

Composite Recycling with Biocatalytic Thermoset Reforming.

Journal of the American Chemical Society·2024
Same author

Transcription Factor Engineering in <i>Aspergillus nidulans</i> Leads to the Discovery of an Orsellinaldehyde Derivative Produced via an Unlinked Polyketide Synthase Gene.

Journal of natural products·2024
Same author

Characterization of natural product inhibitors of quorum sensing reveals competitive inhibition of <i>Pseudomonas aeruginosa</i> RhlR by <i>ortho</i>-vanillin.

Microbiology spectrum·2024

Related Experiment Video

Updated: Mar 22, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

12.1K

Onychomycosis and its Chemotherapy.

Anwer Basha, Fatima Basha1, Syed K Ali

  • 1HEJ Research Institute of chemistry, Karachi university, Karachi, Pakistan. bashafz@gmail.com.

Current Medicinal Chemistry
|April 12, 2016
PubMed
Summary

Onychomycosis, or fungal nail infections, are common but hard to treat. Difficulty in drug penetration to the infection site hinders effective cure, despite new medications.

More Related Videos

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K
Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug&#45;Resistant Candida for Antifungal Research
09:06

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research

Published on: March 29, 2024

1.2K

Related Experiment Videos

Last Updated: Mar 22, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

12.1K
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K
Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug&#45;Resistant Candida for Antifungal Research
09:06

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research

Published on: March 29, 2024

1.2K

Area of Science:

  • Mycology
  • Dermatology
  • Pharmacology

Background:

  • Onychomycosis is a prevalent global fungal infection affecting nails.
  • While not typically life-threatening, it presents significant treatment challenges.

Purpose of the Study:

  • To review the nature of onychomycosis.
  • To discuss causative fungi and their characteristics.
  • To examine the properties of drugs used for treatment.

Main Methods:

  • Literature review of onychomycosis.
  • Analysis of drug penetration challenges.
  • Discussion of treatment characteristics.

Main Results:

  • Fungal nail infections are widespread globally.
  • Current treatments struggle with drug delivery to the infection site.
  • Therapeutic drug concentrations are difficult to achieve.

Conclusions:

  • Onychomycosis treatment is hampered by poor drug penetration.
  • Understanding drug characteristics is key to improving efficacy.
  • Further research into drug delivery is warranted.