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Updated: Mar 22, 2026
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
[Expression of IL-34 in chronic periapical lesions and its clinical significance]
1Department of Endodontics, School of Stomatology, China Medical University; Lab of Endodontics, Liaoning Institute of Dental Research; Research Center of Translational Medicine, Liaoning Provincial Institute of Oral Diseases. Shenyang 110002, Liaoning Province,China.
Purpose:
To observe the expression of IL-34 mRNA in chronic periapical lesions and healthy periodontal ligaments and discuss the role of IL-34 in the etiology of chronic apical periodontitis.
Methods:
A total of 25 periapical tissues from chronic apical periodontitis and 22 normal periodontal ligament tissue from extracted healthy teeth for orthodontic reason were selected. The expression of IL-34mRNA was detected by real-time PCR; the expression of IL-34 protein was detected by immunohistochemical analysis. Statistical analysis was performed using SPSS 13.0 software package.
Results:
The level of IL-34 mRNA expression in periapical lesions (3.53±3.07) was significantly higher than that of the normal control (1.07±0.76); IL-34 was positively expressed in lymphocytes, plasma cells and macrophages. Image analysis software indicated that the level of IL-34 protein was significantly higher in periapical lesions than that in normal control (P<0.01).
Conclusions:
IL-34 may be closely related to inflammation of chronic apical periodontitis.
